The game becomes the second best performing PS4 title in week one sales behind console launch title Killzone: Shadow Fall, according to Chart Track.
The third game in the inFamous series was able to hold off fellow new release Metal Gear Solid V: Ground Zeroes, which enter in second with a strong performance on PlayStation consoles, with the PS4 accounting for 58% of its sales and 15% on PS3.
Titanfall drops down to third this week, whilst the final new release this week; Final Fantasy X/X-2 HD Remaster entered in fourth.
South Park: The Stick of Truth drops down to fifth this week, whilst FIFA 14 holds on to sixth.
Dark Souls II sees a drop down to seventh from its second spot last week, and The LEGO Movie Videogame drops four places to eighth.
Plants vs Zombies: Garden Warfare occupies ninth whilst Top 10 mainstay Minecraft: Xbox 360 Edition drops one place to tenth.
The UK All Formats Chart Top 10 (Week ending 22nd March 2014) is as follows:
1. (N) inFamous: Second Son
2. (N) Metal Gear Solid V: Ground Zeroes
3. (1) Titanfall
4. (N) Final Fantasy X/X-2 HD Remaster
5. (3) South Park: The Stick of Truth
6. (-) FIFA 14
7. (2) Dark Souls II
8. (4) The LEGO Movie Videogame
9. (7) Plants vs Zombies: Garden Warfare
10. (9) Minecraft: Xbox 360 Edition
You can view the full Top 40 here.
Next week sees the introduction of Diablo 3: Reaper of Souls, as well as Professor Layton vs. Phoenix Wright. Will any of these be able to challenge the top? What do you think?